Expanding the ERA Reseach Club – WE NEED YOUR HELP

We are currently expanding the activities of the ERA Research Club to provide you with the support you need for designing, conducting, analysing and disseminating your research work (read the full program description here in PDF). To help us to do so, please consider completing the following short survey: Also we want to set up a postgraduate student focus group, so if you’re willing to participate in the focus group of ERA RC Champions and help develop the curriculum even further, please join while completing the ERA RC survey mentioned above (there is a question for focus group membership). We want to know your ideas, your needs, your views and opinions. However, we will ensure we do not burden you with any additional work.

B lymphocytes: The unknown soldier in the HCC microenvironment

In the concept of immunogenic cancer such as hepatocellular carcinoma (HCC), analysis and studying tumor-infiltrating lymphocytes (TILs) seems to be informative to predict cancer clinical outcomes. Most of TILs contemporary studies aim at T cells as they’re responsible for targeting and killing tumor cells, but T cells cannot work alone. The role of B cells, the other part of lymphocytes, is often ignored. B cells are identified with different densities and within different locations in different stages of HCC.

Survival in colon and rectal cancer through 50 years

Global survival studies have shown favorable development in colon and rectal cancers but few studies have considered extended periods or covered populations for which medical care is essentially free of charge. In this survey colon and rectal cancer survival in Finland and Sweden over a 50-year period (1967-2016) have been analysed. 

DNA Repair Gene Polymorphisms and Chromosomal Aberrations in Exposed Populations

DNA damaged and unrepaired or insufficiently repaired DNA double-strand breaks as well as telomere shortening contribute to the formation of structural chromosomal aberrations (CAs).

Announcing the Nerd Art Prize contest 2021

The ERA Research Club is happy to announce the Nerd Art Prize contest for 2021. Send us your best scientific photo or picture and win the possibility to have it hung as a permanent decoration of the new campus building of the Faculty of Medicine in Pilsen. Also, the winners will be rewarded with surprise gifts. Submission is open and closes on October 31, 2021. Full instruction and information is available here.

DNA repair gene polymorphisms and chromosomal aberrations in healthy, nonsmoking population

Nonspecific structural chromosomal aberrations (CAs) can be found at around 1% of circulating lymphocytes from healthy individuals but the frequency may be higher after exposure to carcinogenic chemicals or radiation. 

Characterization of rare germline variants in familial multiple myeloma

Multiple myeloma (MM) is a malignancy of plasma cells, characterized by the presence of monoclonal immunoglobulin, known as M protein.

Familial occurrence of oropharyngeal and other HPV-associated cancers (OPC)

Prof. Kari HemminkI (European Research Area Chair of Translational Oncology) will provide presentation associate with investigation on Familial occurrence of oropharyngeal and other HPV-associated cancers (OPC) at section Head & Neck Forum – Epidemiology and Screening“ of the EUROGIN meeting.

Germline genetic landscape of colorectal cancers

Prof. Kari Hemminki (European Research Area Chair of Translational Oncology) presented the lecture “Germline genetic landscape of colorectal cancers” in the Colorectal Cancer Symposium of Zhejiang University was held on May 13 to 16, 2021.

Tumor cell and mutational landscape in colorectal cancer development

We are very glad to inform you that the Laboratory of Translational Cancer Genomics will start new project awarded by Czech Health Research Council. The project will be carried out in cooperation with the University Hospital in Pilsen and Institute of Experimental Medicine Czech Academy of Sciences.

Telomere homeostasis as potential biomarker of risk, prognosis and progression in gynaecologic tumours

We are very glad to inform you that the Laboratory of Translational Cancer Genomics will collaborate with  Institute of Experimental Medicine Czech Academy of Sciences and Thomayer hospital on the new project awarded by the Czech Health Research Council.


Blood white cells of healthy individuals may contain non-recurrent, random chromosomal aberrations (CAs), which disappear with cell turnover as they provide no growth advantage. These include chromatid breaks, fragmented or missing parts of chromosomes and fusions resulting in dicentric and ring chromosomes. These nonspecific CAs have been used in monitoring of occupational populations exposed to potential carcinogenic chemicals and radiation. The analysis of CA proceeds in many steps (Figure). The specimen in the figure is the fresh blood sample, which is cultured and harvested for slide preparation; the slides are then analyzed to score CAs.

Project Management Course

European Center Charles University invites you to the Project Management Course which will be held on 19 April 2021.Invitation here.

T-cells as main actors in anti-tumor immunity

The long-suspected role of the importance of immunity in cancer has gained strong experimental support in the past decade. Infiltrating immune cells can function to control tumor growth or to help create an immunosuppressive environment in which the tumor can thrive. Immune surveillance by T-cells in human cancers is one of the key mechanisms of anti-cancer immunity.

Ph.D. Positions at the Biomedical Center

Students for the following Ph.D. study topics are sought in the doctoral study programme: