Hemminki K.; Li X.; Försti A.; Eng C.: Are population level familial risks and germline genetics meeting each other? Hered Cancer Clin Pract. 2023 Mar 8;21(1):3. doi: 10.1189/s13053-023-00247-3
Large amounts of germline sequencing data have recently become available and we sought to compare these results with population-based family history data. Family studies are able to describe aggregation of any defined cancers in families. The Swedish Family-Cancer Database is the largest of its kind in the world, covering the Swedish families through nearly a century with all cancers in family members since the start of national cancer registration in 1958. The database allows estimation of familial risks, ages of cancer onset and the proportion of familial cancer in different family constellations. Here, we review the proportion of familial cancer for all common cancers and specify them based on the number of affected individuals.
A review paper on this topic has recently been published by Laboratory of Translational Cancer Genomics.