F. Ambrozkiewicz, A. Trailin, L. Cervenkova, R. Vaclavikova, V. Hanicinec, M. Al Obeed Allah, R. Palek, V. Treska, O. Daum, Z. Tonar, V. Liška, K. Hemminki: CTNNB1 mutations, TERT polymorphism and CD8+ cell densities in resected hepatocellular carcinoma are associated with longer time to recurrence. BMC Cancer. 2022 Aug 13;22(1):884. doi: 10.1186/s12885-022-09989-0.
Hepatocellular carcinoma (HCC) is a fatal disease characterized by early genetic alterations in telomerase reverse transcriptase promoter (TERTp) and β-catenin (CTNNB1) genes and immune cell activation in the tumor microenvironment. We found out that certain combination of genetic and immune factors improve survival showing higher predictive values. The results outline a novel integrative approach for prognostication through combining independent predictive factors from genetic and immune cell profiles. A detailed overview has been recently published by team from Laboratory of Translational Cancer Genomics.
Kaplan-Meier analysis for time to recurrence according to presence/absence of the CTNNB1 mutation and high/low CD8+ densities in tumor center (A) and invasive margine (B)