Hemminki K, Sundquist K, Sundquist J, Försti A, Liska V, Hemminki A, Li X. Personal comorbidities and their subsequent risks for liver, gallbladder and bile duct cancers. Int J Cancer. 2023 Mar 15;152(6):1107-1114. doi: 10.1002/ijc.34308
Many environmental risk factors for hepatobiliary cancers are known but whether they are associated with specific cancer types is unclear. We present here a novel approach of assessing standardized incidence ratios (SIRs) of previously diagnosed comorbidities for hepatocellular carcinoma (HCC), gallbladder cancer (GBC), cholangiocarcinoma (CCA) and ampullary cancer. The 13 comorbidities included alcohol and nonalcohol related liver disease, chronic obstructive pulmonary disease, gallstone disease, viral and other kinds of hepatitis, infection of bile ducts, hepatic and other autoimmune diseases, obesity and diabetes.
A thorough insight into this topic has recently been published by the team of the Laboratory of Translational Cancer Genomics.