Filip Ambrozkiewicz – member of Translational Cancer Genomics laboratory – attended the EACR 2023 Annual Congress in Torino, Italy and presented poster entitled “MiRNAs as potential biomarkers of hepatocellular carcinoma of non-viral origin”.
In spite of all scientific effort to decipher the tumour biology, hepatocellular carcinoma (HCC) remains the third leading cause of cancer-related deaths. We aimed to assess miRNA profiles in non-viral HCC and their influence on patient outcome such as time to recurrence (TTR), disease-free survival (DFS) and overall survival (OS). We detected 39 differentially expressed miRNA in tumor vs. non-tumor tissue comparison. Additionally, we detected several miRNA not associated with HCC in previous researches (e.g., miR-1973, miR-208a-5p). We found existing correlation between miRNA expression and clinic-pathological variables mainly tumor grade, amount of stroma within tumor, age or gender. Our findings confirm that miRNAs may have impact on patient survival and could be employed as a diagnostic biomarker or target for new therapeutics in prospective investigations of non-viral – associated liver cancer in the European population.